One Step Synthesis of 6-Amino-5-Cyano-4-Phenyl-2-Mercapto Pyrimidine Using Phosphorus Pentoxide

نویسندگان

  • Dipti R. Patil
  • Sonali M. Salunkhe
  • Madhukar B. Deshmukh
  • Prashant V. Anbhule
  • George H. Hitchings
چکیده

A simple and efficient approach towards one step synthesis of 6-amino-5-cyano-4-phenyl-2-mercapto pyrimidine and its hydroxyl derivatives have been developed by three component condensation of aromatic aldehydes, malononitrile and thiourea/urea in presence of phosphorus pentoxide (Scheme 1).

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تاریخ انتشار 2010